High Content Screening Imaging Machine ACQUIFER

HCS Imaging Machine, autom. fluorescence microscope for living cells and zebra fish

ACQUIFER is a division of DITABIS and focused on the development and production of High Content Screening platforms.

The HCS Imaging Machine "ACQUIFER"

We developed our High Content Imaging Machine for easy, precise, robust and smart high content screening applications without the need for an expert to manage the experiment. We focused on integrated data management, long term data transparency, sensitive samples and a robust machine technology that allows Imaging Machines to learn and reproduce protocols from other devices. In other words: HCS Imaging Machines "ACQUIFER" are designed for everyone to use.

More information about the High Content Imaging System are available at the ACQUIFER homepage: https://www.acquifer.de/screening/

Your personalized OEM solution by DITABIS

HCS Imaging machine

Since more than 20 years, DITABIS successfully cooperates with well-known companies in the field of Life Sceince and Diagnostics. As an OEM partner you have the opportunity to get an OEM-Imaging Machine on the basis of our Acquifer-platform especially customized to your application. We make full use of our profound know-how to develop technical and regulative solutions and implement them with great commitment within the shortest possible time. Additionally, our in-house production allows us to be very flexible in cost-efficiently producing your High Content Screening system "Made in Germany".

We look forward to your request!

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Microscope technical details  
User interface:

“App based”, “Standard”, “Advanced” or “Smart imaging“

Specimen specific apps: Zebrafish, yeast, drosophila, cell. organoid, spheroid
Mechanical design: static sample holder, moving optics block; Linear Motors with absolute position encoder, 1 nm resolution
XY axis range: 120 mm x 80 mm, 1 nm resolution, linear motor, absolute encoded
axis range: 25 mm, 1 nm resolution, linear motor , absolute encoded
axis design: optimized for speed and precision
Objectives: 2x, 4x, 10x, 20x, 40x (Nikon)
LED light source: Omicron LED-HUB , up to 6 modules parallel, temperature controlled
LED wavelengths: 340, 369, 385, 405, 455, 470, 505, 528, 595, 625, 660, 730, 820 nm
LED power sensor: Power Sensor at MT plate level
Fluo Filter blocks: custom type, up to 5
Fluo Filter sets duo-quad: in combination with LED light source module for ultra fast switching
Camera: Hamamatsu sCMOS 2k x 2 
Incubation type: robotic lid + integrated laminar flow, pressure free
Incubation range: 20 °C – 40 °C
CO2:  via external controller
Focussing:  Laser Autofocus @780 nm; Image based Autofocus (standard, yeast)
Ambient conditions: 18 °C – 25 °C
Relative humidity: 30 % - 80 %
Power: 120 V – 240 V
Weight: 62 kg
H x W x D: 553 mm x 528 mm x 555 mm

The HCS Imaging Machine „ACQUIFER“ is was developed for applications with living cells and zebrafish. 


  1. Dorsal orientation tool
  2. Lateral orientation tool
  3. Image optimation - Deconvolution
  4. Smart Imaging interface (TCP based)
  5. Visualization tolls


  1. Large / thick 3D specimen
  2. Image optimization / de-blurring
  3. Smart Imaging interface (TCP based)

Time-Lapse Cell Based

  1. Optimized Temperature control – unique laminar flow design for MT plates
  2. Light power sensor at sample level
  3. precise re-positioning (linear motor axis + 1nm resolution encoder)
  4. Laser Autofocus
  5. Smart Imaging Interface (TCP based)


  1. Static MT plate holder (for force sensitive yeast lines)
  2. Laser Autofocus
  3. Yeast optimized image based auto-focus
  4. Image processing workflows
  5. Robotic sample preparation expertise
  6. Smart Imaging interface (TCP based)